Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6
USERS' SCORE
Good
Based on 9 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
10 mg
590%
Calcium (from Calcium Carbonate)
63 mg
4%
Melatonin
3 mg
*
Top Medical Research Studies
2
We evaluated whether melatonin and bright-light phototherapy could help alleviate symptoms of chronic fatigue syndrome (CFS). In a controlled study with thirty participants, we assessed the effectiveness of these treatments by measuring various symptoms over several weeks.
Unfortunately, we found that neither melatonin nor phototherapy led to significant improvements in the patients’ symptoms or overall health. Our findings suggest that these treatments shouldn't be promoted for CFS unless proven beneficial.
Unfortunately, we found that neither melatonin nor phototherapy led to significant improvements in the patients’ symptoms or overall health. Our findings suggest that these treatments shouldn't be promoted for CFS unless proven beneficial.
8
We examined the impact of melatonin on 29 patients with chronic fatigue syndrome (CFS) who had a late Dim Light Melatonin onset (DLMO). Over three months, patients took 5 mg of melatonin five hours before their DLMO.
Both before and after the treatment, we measured their fatigue levels using a reliable questionnaire. After treatment, we saw significant improvements in overall fatigue, concentration, motivation, and activity, especially in patients with a later DLMO.
These findings suggest that melatonin could be a helpful option for managing fatigue in individuals with CFS and delayed melatonin secretion.
Both before and after the treatment, we measured their fatigue levels using a reliable questionnaire. After treatment, we saw significant improvements in overall fatigue, concentration, motivation, and activity, especially in patients with a later DLMO.
These findings suggest that melatonin could be a helpful option for managing fatigue in individuals with CFS and delayed melatonin secretion.
8
We investigated how antioxidants, including melatonin, impact chronic fatigue syndrome (CFS) using a mouse model. In our study, mice were subjected to daily swimming, mimicking fatigue symptoms. We found that melatonin, along with other antioxidants, significantly reduced immobility periods, indicating a potential benefit. Biochemical tests showed that these treatments lessened oxidative stress in the brain, restoring important antioxidant enzyme levels. Overall, the results point to antioxidants, including melatonin, as promising candidates for managing CFS symptoms.
Most Useful Reviews
9.5
Combatting fatigue effectively
An effective product for insomnia, it works quickly and has a lasting impact. It doesn't lead to headaches upon waking, and I can stop using it easily without becoming dependent.
9.5
Facilitates restful sleep
A miraculous remedy for restful sleep! I began using this melatonin when I realised that fatigue and stress were hindering my ability to fall asleep. Initially, I didn't notice any changes for about a week, but then I found it easier to drift off (I take it about an hour before bed) and I can now sleep soundly and for extended periods. It's a wonderful sensation! I use a 3 mg dosage every night, except when I have had a glass of wine.
9.5
Significantly reduces fatigue
Melatonin is a great aid for those with little sleep. Initially, I had my doubts about purchasing it. I take a 3 mg tablet at night, and I feel much better the next day—with no fatigue or effects of sleep deprivation. I highly recommend it!
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6
- All Researches
8
Melatonin and zinc may reduce fatigue
We conducted a 16-week, randomized, double-blind trial to investigate the impact of melatonin combined with zinc on fatigue symptoms in individuals with chronic fatigue syndrome (ME/CFS).
Our research involved 50 participants, where 24 received the active treatment while 26 were given a placebo.
The results were encouraging, showing a significant reduction in fatigue perception and an improvement in overall quality of life for those taking melatonin and zinc.
While urinary levels of melatonin increased significantly, zinc levels did not show notable differences. Overall, this treatment appears safe and potentially beneficial for managing ME/CFS symptoms.
Our research involved 50 participants, where 24 received the active treatment while 26 were given a placebo.
The results were encouraging, showing a significant reduction in fatigue perception and an improvement in overall quality of life for those taking melatonin and zinc.
While urinary levels of melatonin increased significantly, zinc levels did not show notable differences. Overall, this treatment appears safe and potentially beneficial for managing ME/CFS symptoms.
8
We examined the impact of melatonin on 29 patients with chronic fatigue syndrome (CFS) who had a late Dim Light Melatonin onset (DLMO). Over three months, patients took 5 mg of melatonin five hours before their DLMO.
Both before and after the treatment, we measured their fatigue levels using a reliable questionnaire. After treatment, we saw significant improvements in overall fatigue, concentration, motivation, and activity, especially in patients with a later DLMO.
These findings suggest that melatonin could be a helpful option for managing fatigue in individuals with CFS and delayed melatonin secretion.
Both before and after the treatment, we measured their fatigue levels using a reliable questionnaire. After treatment, we saw significant improvements in overall fatigue, concentration, motivation, and activity, especially in patients with a later DLMO.
These findings suggest that melatonin could be a helpful option for managing fatigue in individuals with CFS and delayed melatonin secretion.
8
We investigated how antioxidants, including melatonin, impact chronic fatigue syndrome (CFS) using a mouse model. In our study, mice were subjected to daily swimming, mimicking fatigue symptoms. We found that melatonin, along with other antioxidants, significantly reduced immobility periods, indicating a potential benefit. Biochemical tests showed that these treatments lessened oxidative stress in the brain, restoring important antioxidant enzyme levels. Overall, the results point to antioxidants, including melatonin, as promising candidates for managing CFS symptoms.
7
Melatonin shows mixed benefits for fatigue
We sought to understand how melatonin supplementation affects chronic fatigue syndrome among multiple sclerosis (MS) patients. In our study, 102 patients were divided into groups based on their treatment types and supplemented with melatonin for 90 days.
We found that melatonin significantly reduced plasma lipid hydroperoxide levels, which may relate to chronic fatigue in MS. However, homocysteine levels showed no significant change across the groups after treatment. Overall, while melatonin appeared beneficial in lowering certain biomarkers, it did not significantly alleviate fatigue symptoms in all MS patients.
We found that melatonin significantly reduced plasma lipid hydroperoxide levels, which may relate to chronic fatigue in MS. However, homocysteine levels showed no significant change across the groups after treatment. Overall, while melatonin appeared beneficial in lowering certain biomarkers, it did not significantly alleviate fatigue symptoms in all MS patients.
7
We explored the effects of melatonin on chronic fatigue syndrome (CFS) in patients with Parkinson's disease. Our study involved 30 patients at different stages of the disease.
After treatment, we observed a significant 21% reduction in fatigue severity. Not only did sleep quality improve, but there was also a decrease in anxiety and an enhancement in overall quality of life.
However, we found no noteworthy changes in motor or cognitive functions, nor in depression levels. Melatonin appears promising as part of a treatment plan for CFS and sleep issues in these patients.
After treatment, we observed a significant 21% reduction in fatigue severity. Not only did sleep quality improve, but there was also a decrease in anxiety and an enhancement in overall quality of life.
However, we found no noteworthy changes in motor or cognitive functions, nor in depression levels. Melatonin appears promising as part of a treatment plan for CFS and sleep issues in these patients.
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Combatting fatigue effectively
An effective product for insomnia, it works quickly and has a lasting impact. It doesn't lead to headaches upon waking, and I can stop using it easily without becoming dependent.
9.5
Facilitates restful sleep
A miraculous remedy for restful sleep! I began using this melatonin when I realised that fatigue and stress were hindering my ability to fall asleep. Initially, I didn't notice any changes for about a week, but then I found it easier to drift off (I take it about an hour before bed) and I can now sleep soundly and for extended periods. It's a wonderful sensation! I use a 3 mg dosage every night, except when I have had a glass of wine.
9.5
Significantly reduces fatigue
Melatonin is a great aid for those with little sleep. Initially, I had my doubts about purchasing it. I take a 3 mg tablet at night, and I feel much better the next day—with no fatigue or effects of sleep deprivation. I highly recommend it!
1.3
Lethargy persists
It caused me physical fatigue and lethargy, making it difficult for me to sleep, yet when I did sleep, it was deeply restorative.
9.5
Essential for sleep
Sleep after fatigue must be melatonin! 😍😍
Frequently Asked Questions
9.5
Facilitates restful sleep
A miraculous remedy for restful sleep! I began using this melatonin when I realised that fatigue and stress were hindering my ability to fall asleep. Initially, I didn't notice any changes for about a week, but then I found it easier to drift off (I take it about an hour before bed) and I can now sleep soundly and for extended periods. It's a wonderful sensation! I use a 3 mg dosage every night, except when I have had a glass of wine.
9.5
Significantly reduces fatigue
Melatonin is a great aid for those with little sleep. Initially, I had my doubts about purchasing it. I take a 3 mg tablet at night, and I feel much better the next day—with no fatigue or effects of sleep deprivation. I highly recommend it!
8.8
Not for chronic insomnia
It proved to be an excellent aid in aiding sleep during flights, but one should not expect a miracle if suffering from chronic insomnia.
1.3
Nightmares and fatigue
Below average - it helps me sleep, but it induces nightmares and a sense of fatigue, particularly in my head. It creates nerve fatigue, which I wouldn't recommend.
8.3
Reliable sleep aid
I like this product from the company. It assists significantly. I vary between 1-3 tablets depending on my fatigue and overstimulation. Regardless, I wake up feeling that I have slept well.
8.8
Induces sleep effectively
I find it hard to fall asleep quickly. I dislike the stress I feel when I can't sleep yet have to wake up early. The product is effective! It induces sleep and makes me feel fatigued. Just dim all the lights in the house and give it about 20 minutes to work before sleeping.
8
Melatonin and zinc may reduce fatigue
We conducted a 16-week, randomized, double-blind trial to investigate the impact of melatonin combined with zinc on fatigue symptoms in individuals with chronic fatigue syndrome (ME/CFS).
Our research involved 50 participants, where 24 received the active treatment while 26 were given a placebo.
The results were encouraging, showing a significant reduction in fatigue perception and an improvement in overall quality of life for those taking melatonin and zinc.
While urinary levels of melatonin increased significantly, zinc levels did not show notable differences. Overall, this treatment appears safe and potentially beneficial for managing ME/CFS symptoms.
Our research involved 50 participants, where 24 received the active treatment while 26 were given a placebo.
The results were encouraging, showing a significant reduction in fatigue perception and an improvement in overall quality of life for those taking melatonin and zinc.
While urinary levels of melatonin increased significantly, zinc levels did not show notable differences. Overall, this treatment appears safe and potentially beneficial for managing ME/CFS symptoms.
7
We explored the effects of melatonin on chronic fatigue syndrome (CFS) in patients with Parkinson's disease. Our study involved 30 patients at different stages of the disease.
After treatment, we observed a significant 21% reduction in fatigue severity. Not only did sleep quality improve, but there was also a decrease in anxiety and an enhancement in overall quality of life.
However, we found no noteworthy changes in motor or cognitive functions, nor in depression levels. Melatonin appears promising as part of a treatment plan for CFS and sleep issues in these patients.
After treatment, we observed a significant 21% reduction in fatigue severity. Not only did sleep quality improve, but there was also a decrease in anxiety and an enhancement in overall quality of life.
However, we found no noteworthy changes in motor or cognitive functions, nor in depression levels. Melatonin appears promising as part of a treatment plan for CFS and sleep issues in these patients.
2
We evaluated whether melatonin and bright-light phototherapy could help alleviate symptoms of chronic fatigue syndrome (CFS). In a controlled study with thirty participants, we assessed the effectiveness of these treatments by measuring various symptoms over several weeks.
Unfortunately, we found that neither melatonin nor phototherapy led to significant improvements in the patients’ symptoms or overall health. Our findings suggest that these treatments shouldn't be promoted for CFS unless proven beneficial.
Unfortunately, we found that neither melatonin nor phototherapy led to significant improvements in the patients’ symptoms or overall health. Our findings suggest that these treatments shouldn't be promoted for CFS unless proven beneficial.
2
We explored the impact of melatonin on patients with chronic fatigue syndrome (CFS), focusing on heart rate and blood pressure rhythms. Our study involved 18 CFS patients and measured their ambulatory blood pressure against age-matched controls.
While we saw heightened circadian rhythm amplitudes in CFS patients, melatonin did not improve nighttime blood pressure levels—instead, it worsened hypotension. However, inopamil showed promise in addressing nighttime blood pressure issues.
Ultimately, this suggests that melatonin may not be beneficial for those suffering from CFS.
While we saw heightened circadian rhythm amplitudes in CFS patients, melatonin did not improve nighttime blood pressure levels—instead, it worsened hypotension. However, inopamil showed promise in addressing nighttime blood pressure issues.
Ultimately, this suggests that melatonin may not be beneficial for those suffering from CFS.
8
We examined the impact of melatonin on 29 patients with chronic fatigue syndrome (CFS) who had a late Dim Light Melatonin onset (DLMO). Over three months, patients took 5 mg of melatonin five hours before their DLMO.
Both before and after the treatment, we measured their fatigue levels using a reliable questionnaire. After treatment, we saw significant improvements in overall fatigue, concentration, motivation, and activity, especially in patients with a later DLMO.
These findings suggest that melatonin could be a helpful option for managing fatigue in individuals with CFS and delayed melatonin secretion.
Both before and after the treatment, we measured their fatigue levels using a reliable questionnaire. After treatment, we saw significant improvements in overall fatigue, concentration, motivation, and activity, especially in patients with a later DLMO.
These findings suggest that melatonin could be a helpful option for managing fatigue in individuals with CFS and delayed melatonin secretion.
References
- Castro-Marrero J, Zaragozá MC, López-Vílchez I, Galmés JL, Cordobilla B, et al. Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Antioxidants (Basel). 2021;10. doi:10.3390/antiox10071010
- Adamczyk-Sowa M, Sowa P, Adamczyk J, Niedziela N, Misiolek H, et al. Effect of melatonin supplementation on plasma lipid hydroperoxides, homocysteine concentration and chronic fatigue syndrome in multiple sclerosis patients treated with interferons-beta and mitoxantrone. J Physiol Pharmacol. 2016;67:235.
- Datieva VK, Rosinskaia AV, Levin OS. [The use of melatonin in the treatment of chronic fatigue syndrome and circadian rhythm disorders in Parkinson's disease]. Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113:77.
- van Heukelom RO, Prins JB, Smits MG, Bleijenberg G. Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion. Eur J Neurol. 2006;13:55.
- Singh A, Naidu PS, Gupta S, Kulkarni SK. Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. J Med Food. 2002;5:211.
- Williams G, Waterhouse J, Mugarza J, Minors D, Hayden K. Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy. Eur J Clin Invest. 2002;32:831.
- van de Luit L, van der Meulen J, Cleophas TJ, Zwinderman AH. Amplified amplitudes of circadian rhythms and nighttime hypotension in patients with chronic fatigue syndrome: improvement by inopamil but not by melatonin. Angiology. 1998;49:903.
